Achievement

2025

• Murai K, Kobayashi N, Tarumi W, Nakahata Y, Masui K. Epigenetic dysregulation of high-grade gliomas: from heterogeneity to brain network modulation. Epigenomics in press
• Masui K, Komori A, Morita S, Eguchi S, Kawamata T, Kashiwagi-Hakozaki M, Kurata A, Komori T. Reappraisal of novel molecular parameters for meningioma grading by cIMPACT-NOW update 8 proposals. Brain Tumor Pathol in press
• Koriyama S, Matsui Y, Shioyama T, Onodera M, Tamura M, Kobayashi T, Ro B, Masui K, Komori T, Muragaki Y, Kawamata T. High-precision intraoperative diagnosis of gliomas: integrating imaging and intraoperative flow cytometry with machine learning. Front Neurol in press
• Odate T, Lami K, Tsuyama N, Mori I, Kiriyama Y, Teramoto N, Masuzawa Y, Sukhbaatar O, Masui K, Yoon HS, Fukuoka J. Diagnostic challenges of faded hematoxylin and eosin slides: limitations of re-staining and re-sectioning and possible reason to go digital. Virchows Arch in press
• Shibata N, Kataoka I, Okamura Y, Murakami K, Kato Y, Yamamoto T, Masui K. Implications for soluble iron accumulation, oxidative stress, and glial glutamate release in motor neuron death associated with sporadic amyotrophic lateral sclerosis. Neuropathology 45: 177-201, 2025
• Masui K, Onizuka H, Muragaki Y, Kawamata T, Kurata A, Komori T. Progression of long-term "untreated" oligodendroglioma cases: possible contribution of genomic instability. Brain Tumor Pathol 42: 43-47, 2025
• Masui K, Onizuka H, Muragaki Y, Kawamata T, Nagashima Y, Kurata A, Komori T. Integrated assessment of malignancy in IDH-mutant astrocytoma with p16 and methylthioadenosine phosphorylase immunohistochemistry. Neuropathology 45: 66-75, 2025

2024

• Kuatov R, Takano J, Arie H, Kominami M, Tateishi N, Wakabayashi KI, Takemoto D, Izumo T, Nakao Y, Nakamura W, Shinohara K, Nakahata Y. Urolithin A Modulates PER2 Degradation via SIRT1 and Enhances the Amplitude of Circadian Clocks in Human Senescent Cells. Nutrients 17: 20, 2025
• Le MK, Kawai M, Masui K, Komori T, Kawamata T, Muragaki Y, Inoue T, Tahara I, Kasai K, Kondo T. Glioma Image-Level and Slide-Level Gene Predictor (GLISP) for Molecular Diagnosis and Predicting Genetic Events of Adult Diffuse Glioma. Bioengineering 12: 12, 2024
• Masui K, Onizuka H, Muragaki Y, Kawamata T, Kurata A, Komori T. Intratumoral heterogeneity of CDKN2A deletions in IDH-mutant astrocytoma. Brain Tumor Pathol 41: 92-95, 2024
• Harachi M, Masui K, Shimizu E, Murakami K, Onizuka H, Muragaki Y, Kawamata T, Nakayama H, Miyata M, Komori T, Cavenee WK, Mischel PS, Kurata A, Shibata N. DNA hypomethylator phenotype reprograms glutamatergic network in receptor tyrosine kinase gene-mutated glioblastoma. Acta Neuropathol Commun 12: 40, 2024
• Serizawa M, Serizawa K, Masui K, Toguchi M, Murakami K, Yamamoto T, Nagashima Y, Takagi T, Kurata A. Metabolic and Epigenetic Reprogramming in a Case of Nuclear Protein in Testis (NUT) Carcinoma of the Retroperitoneum. Cureus 16: e52814, 2024
• Oda H, Omichi E, Oda E, Shinohara R, Oda H, Aoyama S, Tarumi W, Ling X, Shinohara K, Nakahata Y. Comparative analysis of chronological and biological aging on the potential of in vitro cultured human adipose-derived mesenchymal stem cells. Acta Med Nagasaki 67: 49-60, 2024

2023

• Masui K, Mischel PS. Metabolic and epigenetic reprogramming in the pathogenesis of glioblastoma: Toward the establishment of "metabolism-based pathology". Pathol Int 73: 533-541, 2023
• Masui K, Nitta M, Muragaki Y, Kawamata T, Satomi K, Matsushita Y, Yoshida A, Ichimura K, Tsuda M, Tanaka S, Komori T. A case of "genetically defined" radiation-induced glioma: 29 years after surgery and radiation for pilocytic astrocytoma. Neuropathology 43: 425-428, 2023
• Masui K, Onizuka H, Nitta M, Muragaki Y, Kawamata T, Komori T. Recurrent high-grade astrocytoma with somatic mosaicism of isocitrate dehydrogenase gene mutation. Pathol Int 73: 144-146, 2023

2022

• Chang PY, Chin LC, Kimura K, Nakahata Y. Human placental extract activates a wide array of gene expressions related to skin functions. Sci Rep 12: 11031, 2022
• Huang L, Chin LC, Kimura K, Nakahata Y. Human Placental Extract Delays In Vitro Cellular Senescence through the Activation of NRF2-Mediated Antioxidant Pathway. Antioxidants (Basel) 11: 1545, 2022
• Nakagaki T, Kaneko M, Satoh K, Murai K, Saiki K, Matsumoto G, Ogami-Takamura K, Ikematsu K, Akagi A, Iwasaki Y, Tsurumoto T, Nishida N. Detection of Prions in a Cadaver for Anatomical Practice. N Engl J Med 386: 2245-2246, 2022
• Nakahata Y, Fukada Y. Molecular connections between circadian clock and health/aging. J Biochem 171: 473-476, 2022
• Ahmed R, Reza HM, Shinohara K, Nakahata Y. Cellular Senescence and its Impact on the Circadian Clock. J Biochem 171: 493-500, 2022
• Masui K, Cavenee WK, Mischel PS, Shibata N. The metabolomic landscape plays a critical role in glioma oncogenesis. Cancer Sci 113: 1555-1563, 2022

2021

• Onizuka H, Masui K, Amano K, Kawamata T, Yamamoto T, Nagashima Y, Shibata N. Metabolic Reprogramming Drives Pituitary Tumor Growth through Epigenetic Regulation of TERT. Acta Histochem Cytochem 54: 87-96, 2021
• Ashimori A, Nakahata Y, Sato T, Fukamizu Y, Matsui T, Shinohara K, Bessho Y. Attenuated SIRT1 activity leads to PER2 cytoplasmic localization and dampens the amplitude of Bmal1 promoter-driven circadian oscillation. Front Neurosci 15: 64758, 2021
• Harachi M, Masui K, Cavenee WK, Mischel PS, Shibata N. Protein Acetylation at the Interface of Genetics, Epigenetics and Environment in Cancer. Metabolites 11: 216, 2021
• Khaidizar FD, Bessho Y, Nakahata Y Nicotinamide Phosphoribosyl-transferase as a Key Molecule of the Aging/Senescence Process. Int J Mol Sci. 22: 3709, 2021
• Ahmed R, Nakahata Y, Shinohara K, Bessho Y. Cellular Senescence Triggers Altered Circadian Clocks With a Prolonged Period and Delayed Phases. Front Neurosci 15: 638122, 2021

2020

• Kazama M, Kato Y, Kakita A, Noguchi N, Urano Y, Masui K, Niida-Kawaguchi M, Yamamoto T, Watabe K, Kitagawa K, Shibata N. Astrocytes release glutamate via cystine/glutamate antiporter upregulated in response to increased oxidative stress related to sporadic amyotrophic lateral sclerosis. Neuropathology 40: 587-598, 2020
• Asai T, Abe D, Doi H, Tanaka C, Ohishi K, Maeda H, Wada T, Takahashi Y, Nakahata Y, Shinohara K. Characteristics of the BDNF Val66Met polymorphism in competitive swimmers and judo athletes. Acta Med Nagasaki 64: 23-29, 2020
• Tarumi W, Shinohara K. Olfactory Exposure to β-Caryophyllene Increases Testosterone Levels in Women's Saliva. Sex Med 8: 525-531, 2020
• Nuriliani A, Nakahata Y, Ahmed R, Khaidizar FD, Matsui T, Bessho Y. Overexpression of Nicotinamide phosphoribosyltransferase in mouse cells confers a protective effect against oxidative and ER stress-induced premature senescence. Genes Cells 25: 593–602, 2020
• Harachi M, Masui K, Honda H, Muragaki Y, Kawamata T, Cavenee WK, Mischel PS, Shibata N. Dual Regulation of Histone Methylation by mTOR Complexes Controls Glioblastoma Tumor Cell Growth via EZH2 and SAM. Mol Cancer Res 18: 1142-1152, 2020
• Masui K, Harachi M, Cavenee WK, Mischel PS, Shibata N. mTOR complex 2 is an integrator of cancer metabolism and epigenetics. Cancer Lett 478: 1-7, 2020
• Niida-Kawaguchi M, Kakita A, Noguchi N, Kazama M, Masui K, Kato Y, Yamamoto T, Sawada T, Kitagawa K, Watabe K, Shibata N. Soluble iron accumulation induces microglial glutamate release in the spinal cord of sporadic amyotrophic lateral sclerosis. Neuropathology 40: 152-166, 2020
• Tarumi W, Shinohara K. The Effects of Essential Oil on Salivary Oxytocin Concentration in Postmenopausal Women. J Altern Complement Med 26: 226-230, 2020
• Tarumi W, Shinohara K. Women's body odour during the ovulatory phase modulates testosterone and cortisol levels in men. PLoS One 15: e0230838, 2020
• Masui K, Harachi M, K Cavenee W, S Mischel P, Shibata N. Codependency of Metabolism and Epigenetics Drives Cancer Progression: A Review. Acta Histochem Cytochem 253: 1-10, 2020
• Qiu R, Murai K, Lu Q. Spindle orientation-independent control of cell fate determination by RGS3 and KIF20A. Cereb Cortex Commun 1: 1-7, 2020
• Bi J, Chowdhry S, Wu S, Zhang W, Masui K, Mischel PS. Altered cellular metabolism in gliomas - an emerging landscape of actionable co-dependency targets. Nat Rev Cancer 20: 57-70, 2020

2019以前

• Masui K, Harachi M, Ikegami S, Yang H, Onizuka H, Yong WH, Cloughesy TF, Muragaki Y, Kawamata T, Arai N, Komori T, Cavenee WK, Mischel PS, Shibata N. mTORC2 links growth factor signaling with epigenetic regulation of iron metabolism in glioblastoma. J Biol Chem 294: 19740-19751, 2019
• Ahmed R, Ashimori A, Iwamoto S, Matsui T, Nakahata Y, Bessho Y. Replicative senescent human cells possess altered circadian clocks with a prolonged period and delayed peak-time. Aging (Albany NY) 11: 950-973, 2019
• Nakahata Y, Yasukawa S, Khaidizar FD, Shimba S, Matsui T, Bessho Y. Bmal1-deficient mouse fibroblast cells do not provide premature cellular senescence in vitro. Chronobiol Int 35: 730-738, 2018
• Masui K, Komori T, Kato Y, Masutomi K, Ichimura K, Ogasawara S, Kaneko MK, Oki H, Suzuki H, Nitta M, Maruyama T, Muragaki Y, Kawamata T, Sawada T, Shibata N. Elevated TERT Expression in TERT-Wildtype Adult Diffuse Gliomas: Histological Evaluation with a Novel TERT-Specific Antibody. Biomed Res Int 2018: 7945845, 2018
• Khaidizar FD, Nakahata Y, Kume A, Sumizawa K, Kohno K, Matsui T, Bessho. Nicotinamide phosphoribosyltransferase delays cellular senescence by upregulating SIRT1 activity and antioxidant gene expression in mouse cells. Genes Cells 22: 982-992, 2017
• Masui K, Shibata N, Cavenee WK, Mischel PS. mTORC2 activity in brain cancer: Extracellular nutrients are required to maintain oncogenic signaling. Bioessays 38: 839-44, 2016
• Murai K, Sun G, Ye P, Tian E, Yang S, Cui Q, Sun G, Trinh D, Sun O, Hong T, Wen Z, Kalkum M, Riggs AD, Song H, Ming GL, Shi Y. The TLX-miR-219 cascade regulates neural stem cell proliferation in neurodevelopment and schizophrenia iPSC model. Nat Commun 7: 10965, 2016
• Masui K, Cavenee WK, Mischel PS. mTORC2 and Metabolic Reprogramming in GBM: at the Interface of Genetics and Environment. Brain Pathol 25: 755-9, 2015
• Masui K, Tanaka K, Ikegami S, Villa GR, Yang H, Yong WH, Cloughesy TF, Yamagata K, Arai N, Cavenee WK, Mischel PS. Glucose-dependent acetylation of Rictor promotes targeted cancer therapy resistance. Proc Natl Acad Sci U S A 112: 9406-11, 2015
• Masui K, Cavenee WK, Mischel PS. mTORC2 in the center of cancer metabolic reprogramming. Trends Endocrinol Metab 25: 364-73, 2014
• Murai K, Qu Q, Sun G, Ye P, Li W, Asuelime G, Sun E, Tsai GE, Shi Y. Nuclear receptor TLX stimulates hippocampal neurogenesis and enhances learning and memory in a transgenic mouse model. Proc Natl Acad Sci U S A 111: 9115-20, 2014
• Tarumi W, Itoh MT, Suzuki N. Effects of 5α-dihydrotestosterone and 17β-estradiol on the mouse ovarian follicle development and oocyte maturation. PLoS One 9: e99423, 2014
• Nathanson DA, Gini B, Mottahedeh J, Visnyei K, Koga T, Gomez G, Eskin A, Hwang K, Wang J, Masui K, Paucar A, Yang H, Ohashi M, Zhu S, Wykosky J, Reed R, Nelson SF, Cloughesy TF, James CD, Rao PN, Kornblum HI, Heath JR, Cavenee WK, Furnari FB, Mischel PS. Targeted therapy resistance mediated by dynamic regulation of extrachromosomal mutant EGFR DNA. Science 343: 72-6, 2014
• Masui K, Tanaka K, Akhavan D, Babic I, Gini B, Matsutani T, Iwanami A, Liu F, Villa GR, Gu Y, Campos C, Zhu S, Yang H, Yong WH, Cloughesy TF, Mellinghoff IK, Cavenee WK, Shaw RJ, Mischel PS. mTOR complex 2 controls glycolytic metabolism in glioblastoma through FoxO acetylation and upregulation of c-Myc. Cell Metab 18: 726-39, 2013
• Babic I, Anderson ES, Tanaka K, Guo D, Masui K, Li B, Zhu S, Gu Y, Villa GR, Akhavan D, Nathanson D, Gini B, Mareninov S, Li R, Camacho CE, Kurdistani SK, Eskin A, Nelson SF, Yong WH, Cavenee WK, Cloughesy TF, Christofk HR, Black DL, Mischel PS. EGFR mutation-induced alternative splicing of Max contributes to growth of glycolytic tumors in brain cancer. Cell Metab 17: 1000-1008, 2013
• Zhang RR, Cui QY, Murai K, Lim YC, Smith ZD, Jin S, Ye P, Rosa L, Lee YK, Wu HP, Liu W, Xu ZM, Yang L, Ding YQ, Tang F, Meissner A, Ding C, Shi Y, Xu GL. Tet1 regulates adult hippocampal neurogeneis and cognition. Cell Stem Cell 13: 237-45, 2013
• Masui K, Gini B, Wykosky J, Zanca C, Mischel PS, Furnari FB, Cavenee WK. A tale of two approaches: complementary mechanisms of cytotoxic and targeted therapy resistance may inform next-generation cancer treatments. Carcinogenesis 34: 725-38, 2013
• Bellet MM, Nakahata Y, Boudjelal M, Watts E, Mossakowska DE, Edwards KA, Cervantes M, Astarita G, Loh C, Ellis JL, Vlasuk GP, Sassone-Corsi P. Pharmacological modulation of circadian rhythms by synthetic activators of the deacetylase SIRT1. Proc Natl Acad Sci U S A 2013; 110(9):3333-3338.
• Li S, Sun G, Murai K, Ye P, Shi Y. Characterization of TLX expression in Neural Stem Cells and Progenitor Cells in Adult Brains. PLoS One 7: e43324, 2012
• Tarumi W, Tsukamoto S, Okutsu Y, Takahashi N, Horiuchi T, Itoh MT, Ishizuka B. Androstenedione induces abnormalities in morphology and function of developing oocytes, which impairs oocyte meiotic competence. Fertil Steril 97: 469-76, 2012
• Sun G, Ye P, Murai K, Lang MF, Li S, Zhang H, Li W, Fu C, Yin J, Wang A, Ma X, Shi Y. miR-137 forms a regulatory loop with nuclear receptor TLX and LSD1 in neural stem cells. Nat Commun 2: 529, 2011
• Vlashi E, Lagadec C, Vergnes L, Matsutani T, Masui K, Poulou M, Popescu R, Della Donna L, Evers P, Dekmezian C, Reue K, Christofk H, Mischel PS, Pajonk F. Metabolic state of glioma stem cells and nontumorigenic cells. Proc Natl Acad Sci U S A 108: 16062-7, 2011
• Masui K, Suzuki SO, Torisu R, Goldman JE, Canoll P, Iwaki T. Glial progenitors in the brainstem give rise to malignant gliomas by platelet-derived growth factor stimulation. Glia 58: 1050-65, 2010
• Murai K, Qiu R, Zhang H, Wang J, Wu C, Neubig RR, Lu Q. Gα subunit coordinates with ephrin-B to balance self-renewal and differentiation in neural progenitor cells. Stem Cells 28: 1581-9, 2010
• Nakahata Y, Sahar S, Astarita G, Kaluzova M, Sassone-Corsi P. Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1. Science 324, 654-657, 2009
• Nakahata Y, Kaluzova M, Grimaldi B, Sahar S, Hirayama J, Chen D, Guarente LP, Sassone-Corsi P. The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. Cell 134, 329-340, 2008
• Masui K, Mawatari SY, Suzuki SO, Iwaki T. Evaluation of sensitivity and specificity of doublecortin immunostatining for the detection of infiltrating glioma cells. Brain Tumor Pathol 25: 1-7, 2008
• Hirayama J, Sahar S, Grimaldi B, Tamaru T, Takamatsu K, Nakahata Y, Sassone-Corsi P. CLOCK-mediated acetylation of BMAL1 controls circadian function. Nature 450: 1086-1090, 2007
• Nomura M, Uda-Tochio H, Murai K, Mori N, Nishimura Y. The neural repressor NRSF/REST binds the PAH1 domain of the Sin3 corepressor by using its distinct short hydrophobic helix. J Mol Biol 354: 903-15, 2005
• Murai K, Naruse Y, Shaul Y, Agata Y, Mori N. Direct interaction of NRSF with TBP: chromatin reorganization and core promoter repression for neuron-specific gene transcription. Nucleic Acids Res 2004 32: 3180-9, 2004